| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 70632 | Journal of Molecular Catalysis B: Enzymatic | 2009 | 5 Pages |
Abstract
A novel and efficient chemoenzymatic protocol for the preparation of both enantiomers of trans-2-aminocyclopentanol is described. The key steps of this strategy are the synthesis and subsequent Burkholderia cepacia lipase-catalyzed resolution of the racemic precursor trans-2-(diallylamino)cyclopentanol. In addition, a variety of diversely substituted derivatives are prepared from the enantiopure compounds isolated in the biotransformation by means of simple protection–deprotection reactions.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Javier González-Sabín, Francisco Morís-Varas, Carmen Peña, Francisca Rebolledo, Vicente Gotor,