| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 70704 | Journal of Molecular Catalysis B: Enzymatic | 2009 | 6 Pages |
Abstract
A simple and efficient method for the synthesis of optically active γ-azidoalcohols is described. The lipase catalyzed kinetic resolutions of acetates of γ-azidoalcohols in aqueous as well as organic media have been studied. The enantiomerically pure γ-azidoalcohols obtained by the kinetic resolution in high enantiopurity have been utilized towards the synthesis of enantiomeric pairs of anti-depressant drugs, fluoxetine and duloxetine.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik, Shaik Azeeza,