Article ID Journal Published Year Pages File Type
70791 Journal of Molecular Catalysis B: Enzymatic 2008 7 Pages PDF
Abstract

The biotransformation of four taxadienes, 2α,5α-diacetoxy-14β-hydroxy-10β-methoxytaxa-4(20),11(12)-diene (1), 10β-methoxy-2α,5α,14β-triacetoxytaxa-4(20),11(12)-diene (2), 2α,5α,10β-triacetoxytaxa-4(20),11(12)-dien-13-one (3), and 2α,5α-diacetoxy-10β-methoxytaxa-4(20),11(12)-dien-13-one (4) were individually investigated by the cultured cells of Ginkgo biloba. Six new metabolites together with four known metabolites were obtained from their biotransformations. Most compounds were evaluated for the MDR reversal activity against taxol-resistant human non-small cell lung cancer (NSCLC)-lung adenocarcinoma cell line, A549/taxol. Two compounds, 5 and 6, exhibited significant MDR reversal activity when co-administered with taxol at 5 μM. The result showed that the methoxyl group at C-10 and hydroxyl group at C-14 may be potential pharmacophores with taxadiene MDR reversal agents.

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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