Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
70828 | Journal of Molecular Catalysis B: Enzymatic | 2008 | 4 Pages |
Abstract
A simple chemo-enzymatic strategy for the synthesis of functionalized poly(1,5-dioxepane-2-one)esters has been developed. The protocol involves first the reaction of a primary amine with 1,5-dioxepane-2-one (2) to give an amide carrying a terminal primary hydroxyl group, followed by an enzymatic ring-opening polymerization catalyzed by Novozym 435. The proposed method is easy to handle and is suitable for the incorporation of different amines, as it has been shown with the model benzyl amine (3), the functionalized amines tyramine (4) and propargylamine (5), and the bioactive compound N-deacetylthiocolchicine (6).
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Mattia Marzorati, Cristina Navarra, Raniero Mendichi, Sergio Riva, Bruno Danieli,