| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 70862 | Journal of Molecular Catalysis B: Enzymatic | 2010 | 5 Pages |
Solvent-free domino acylation/cyclization reactions between fatty acid esters and o-phenylenediamine mediated by immobilized lipase from Mucor miehei (MML) were found to be an efficient way in the synthesis of 2-alkylbenzimidazole. Compared with other substrates, methyl fatty acid esters with moderated chain length exhibited best activity with yield up to 95%. The mechanism of the domino process was clarified deeply through some detail experiments, including separation of intermediates. This efficient enzymatic domino process provides an attractive procedure for heterocyclic compound synthesis and could be regarded as a potential synthetic method in modern organic chemistry.
Graphical abstractSolvent-free domino acylation/cyclization reaction between fatty acid esters and o-phenylenediamine catalyzed by immobilized lipase from Mucor miehei (MML) was found to be an efficient way in the synthesis of 2-alkylbenzimidazole.Figure optionsDownload full-size imageDownload as PowerPoint slide
