Article ID Journal Published Year Pages File Type
70897 Journal of Molecular Catalysis B: Enzymatic 2007 7 Pages PDF
Abstract

Methyleneketoesters were readily prepared in high yields by performing a direct α-methylenation of the corresponding ketoesters using a previously described protocol. Reactions of ethyl 2-methylene-3-oxo-3-arylpropanoates 2a–c catalyzed by S. cerevisiae were performed with good conversions to give reductions of the CC, CO or both, depending on the reaction conditions and on the substitution of the aryl moiety. Reaction of 3-methylene-2-oxo-4-phenylbutyrate 2d was carried out with free yeast cells and with yeast cells immobilized with calcium alginate, in which the major products resulted from CC and CO bond reduction.

Related Topics
Physical Sciences and Engineering Chemical Engineering Catalysis
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