| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 70912 | Journal of Molecular Catalysis B: Enzymatic | 2008 | 5 Pages |
Abstract
A novel telluric hyaluronic acid (TeHA) compound was synthesized to imitate the antioxidant enzyme glutathione peroxidase (GPX). The GPX activity of the mimic was found to be 164 U/μmol, which is 165 times as active as Ebselen [PZ51], a well-known GPX mimic. Antioxidant activity was studied by using a ferrous sulfate/ascorbate (Fe2+/Vc)-induced mitochondria damage model system. TeHA markedly decreased the swelling of mitochondria, inhibited the lipid peroxidation, maintained the activity of cytochrome c oxidase, and exhibited excellent antioxidant ability.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Zhibo Chen, Jianwei Lv, Fengqing Chen, Lidong Lin,