Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
70913 | Journal of Molecular Catalysis B: Enzymatic | 2008 | 6 Pages |
Abstract
Both enantiomers of 2,2′-dihydroxy-4,4′,5,5′,6,6′-hexamethybiphenyl (2), a potentially useful chiral synthon, were obtained with >99% ee in high enantioselectivity by cholesterol esterase or porcine pancreas lipase (PPL)-mediated hydrolysis of the corresponding (±)-dipentanoate or (±)-dihexanoate, respectively. Absolute configuration of (S)-3-bromo-2,6′-dimethoxy-4,5,6,2′,3′,4′-hexamethyl-biphenyl (2h) was determined by X-ray analysis.
Related Topics
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Authors
Tetsuo Takemura, Go Emoto, Jun Satoh, Yoshitaka Kobayashi, Chihiro Yaginuma, Yuta Takahashi, Takamitsu Utsukihara, C. Akira Horiuchi,