Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
70923 | Journal of Molecular Catalysis B: Enzymatic | 2008 | 5 Pages |
Abstract
Aspergillus oryzae OUT5048 and Fusarium roseum OUT4019 were found to be effective biocatalysts in the reduction of benzils to optically active benzoins. Easily available symmetrical benzil derivatives were reduced to the corresponding benzoins [(S)-2-hydroxy-1,2-diphenylethanones] by A. oryzae OUT5048 with up to 94% ee and by F. roseum OUT4019 with up to 98% ee, respectively. In this work, first general method for whole-cell-mediated selective reduction of benzils to benzoins is reported. It is also shown that this method is applicable for benzils with both electron-withdrawing and electron-donating groups.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Ayhan S. Demir, Peruze Ayhan, Umut Demirtaş, Umut Erkılıç,