| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 71045 | Journal of Molecular Catalysis B: Enzymatic | 2008 | 5 Pages |
Abstract
Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol (5) is described using vinyl acetate as acyl donor. The effect of different lipases from various sources in several solvents has been studied. This intermediate 5 is utilized in the preparation of enantiomerically enriched (R) and (S)-timolol.
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Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
![Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol: Synthesis of (R)- and (S)-timolol](/preview/png/71045.png "First Page Preview: Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol: Synthesis of (R)- and (S)-timolol")
Authors
Ahmed Kamal, Tadiparthi Krishnaji, M. Naseer A. Khan,