Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
71067 | Journal of Molecular Catalysis B: Enzymatic | 2006 | 5 Pages |
Abstract
Lipases from Mucor miehei (MML) and Candida antarctica (CAL) are able to catalyze the monobenzoylation of the primary hydroxy group of 1,2- 1,4- or 1,5-diols with vinyl benzoate in an organic solvent, the reaction proceeding with high regioselectivity and moderate enantioselectivity. The lipase-catalyzed debenzoylation of 1,2-propanediol dibenzoate by alcoholysis with 1-octanol most satisfactorily occurred with Pseudomonas cepacia lipase absorbed onto celite that allowed also to prepare (R)-1-benzoyloxy-2-methylpropan-3-ol from 2-methyl-1,3-propanediol dibenzoate, a result complementary to MML-catalyzed benzoylation of 2-methyl-1,3-propanediol that affords the (S)-monobenzoate.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Enzo Santaniello, Pierangela Ciuffreda, Silvana Casati, Laura Alessandrini, Alessandro Repetto,