Patient-specific optimal cooling power command for hypothermia induction by liquid ventilation

While it is known that total liquid ventilation can rapidly cool animal subjects and improve outcomes after cardiac arrest, the temperature control strategy of the liquid ventilator for clinical use remains unknown. This work proposes to control the cooling power of the liquid ventilator in two phases. The first phase consists in a null cooling power command in order to estimate cardiac output. During the second phase, the optimal cooling power command dedicated to the estimated cardiac output is sent to the cooling system. The simulated results in human adults allow predicting the cooling performances and the overall safety.