| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 71104 | Journal of Molecular Catalysis B: Enzymatic | 2007 | 4 Pages |
Abstract
A novel synthetic route to rimexolone, a corticosteroid for treatment of ocular inflammation without significant elevation of intraocular pressure, was described. An investigation has been undertaken of the microbial transformation of 16α,17α-dimethyl-17β-(l-oxopropyl)androsta-l,4-dien-3-one by microorganisms known to hydroxylate conventional steroids, using Curvularia lunata AS 3.4381 gave rimexolone, the product of 11β-hydroxylation, respectively. The target compound was characterized with reference substance rimexolone by TLC, HPLC, elemental analysis, MS, IR, and NMR.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Jiong Yang, Shunkai Yang, Ya-Li Yang, Hu Zheng, Lingling Weng, Luo Liu,