| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 71225 | Journal of Molecular Catalysis B: Enzymatic | 2006 | 7 Pages |
Abstract
The biocatalytic properties of three Baeyer–Villiger monooxygenases (phenylacetone monooxygenase, 4-hydroxyacetophenone monooxygenase and ethionamide monooxygenase) in a variety of aqueous–organic media were studied using organic sulfides as substrates. The influence of the nature and the concentration of the solvents, as well as of the substrates, on the activity and enantioselectivity of the enzymes was investigated in detail. Solvents were found to decrease, to a different extent, enzyme activity. High increases of enantioselectivity and also reversal of enantiopreference were observed depending on the enzyme and on the nature of the solvent and the substrate employed.
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Authors
Gonzalo de Gonzalo, Gianluca Ottolina, Francesca Zambianchi, Marco W. Fraaije, Giacomo Carrea,