Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
71263 | Journal of Molecular Catalysis B: Enzymatic | 2006 | 6 Pages |
Abstract
This study was investigated for the enantioselective separation of (S)-ibuprofen using the ionic liquid in the microfluidic device. A stable and thin ionic liquid flow (ILF) was made by controlling the flow rate of the ILF in the microfluidic channel. In addition, coupling lipase as a biocatalyst with the ILF based on the microfluidic device showed the facilitative and selective transport of (S)-ibuprofen across the ILF, indicating successful optical resolution of a racemic mixture. Subsequently, the enantioselectivity was evaluated in the transport ratio (η) of (R)- and (S)-ibuprofen, the optical resolution ratio (α) and enantiomeric excess of (S)-ibuprofen (eeS).
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
Yun Suk Huh, Young-Si Jun, Yeon Ki Hong, Won Hi Hong, Do Hyun Kim,