Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
71299 | Journal of Molecular Catalysis B: Enzymatic | 2006 | 6 Pages |
Abstract
A porcine pancreatic lipase mediated enzymatic hydrolysis of (±)-1-acetoxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyltetrahydro-indane (5b) furnished (1S,7aS)-1-acetoxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyltetrahydro-indane (9) and (1R,7aR)-1-hydroxy-5-oxo-4-(2′-carbomethoxyethyl)-7a-methyltetrahydro-indane (8) with >99% e.e. which on further chemical hydrolysis gave 1 and ent-1, key intermediates of steroids.
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Authors
Uttam R. Kalkote, Abhijeet N. Purude, Vedavati G. Puranik, Mukund K. Gurjar,