Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7139177 | Sensors and Actuators B: Chemical | 2018 | 32 Pages |
Abstract
Alendronate sodium (ALDS) is an important and regularly used medicine in clinical therapy of osteoporosis. In this work, a new analytical method is developed for the detection of ALDS based on a fluorescent platform of copper(II)-mediated silver nanoclusters (AgNCs). Specifically, Cu2+ can selectively bind with DNA-stabilized AgNCs and thus greatly quench their red fluorescence. In the presence of ALDS, their fluorescence can largely recover again owing to the stronger coordination of ALDS with Cu2+. On the basis of such a mechanism, fluorescence “on-off-on” mode of the nanoprobe is applied to detect ALDS in a wide linear range of 800 pM-200â¯Î¼M, with a detection limit of 100â¯pM. Compared with previously reported methods, the present approach has significant advantages regard to simplicity, high sensitivity, and a wide detectable concentration range. This method has been successfully applied in ALDS assay in tablets and human body fluids.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Chunyan Jia, Jingchuan Shang, Yi Wang, Lijuan Bai, Chao Tong, Yongjie Chen, Pu Zhang,