Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7139521 | Sensors and Actuators B: Chemical | 2018 | 34 Pages |
Abstract
The amino-functionalized metal organic framework (NH2-Cu-MOF) was fabricated via bottom-up synthesis strategy. Detailed characterization using electron microscopy, X-ray photoelectron spectroscopy and atomic force microscopy demonstrated that the as-synthesized NH2-Cu-MOF was two-dimensional nanosheet (a thin thickness â¼4.2â¯nm). Results showed that the as-synthesized NH2-Cu-MOF nanosheet possessed fluorescence property (λemâ¯=â¯425â¯nm) as well as peroxidase mimic activity. On the basis of these two properties, we proposed a biosensor for hypoxanthine detection. The fluorescence intensity had a linear relationship with the hypoxanthine concentration in the range of 10-2000â¯Î¼M. The limit of detection was 3.93â¯Î¼M (S/Nâ¯=â¯3). This work contributes to the synthesis of a new two-dimensional MOF nanosheet and extends the application of two-dimensional MOF nanosheet on biological luminescent sensors.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Shuisheng Hu, Jingjing Yan, Xueming Huang, Longhua Guo, Zhenyu Lin, Fang Luo, Bin Qiu, Kwok-Yin Wong, Guonan Chen,