Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7142571 | Sensors and Actuators B: Chemical | 2017 | 7 Pages |
Abstract
We demonstrate a surface plasmon resonance imaging platform integrated with a smartphone to be used in the field with high-throughput biodetection. Inexpensive and disposable SPR substrates are produced by metal coating of commercial Blu-ray discs. A compact imaging apparatus is fabricated using a 3D printer which allows taking SPR measurements from more than 20.000 individual pixels. Real-time bulk refractive index change measurements yield noise equivalent refractive index changes as low as 4.12Â ÃÂ 10â5 RIU which is comparable with the detection performance of commercial instruments. As a demonstration of a biological assay, we have shown capture of mouse IgG antibodies by immobilized layer of rabbit anti-mouse (RAM) IgG antibody with nanomolar level limit of detection. Our approach in miniaturization of SPR biosensing in a cost-effective manner could enable realization of portable SPR measurement systems and kits for point-of-care applications.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Hasan Guner, Erol Ozgur, Guzin Kokturk, Mehmet Celik, Elif Esen, Ahmet E. Topal, Sencer Ayas, Yildiz Uludag, Caglar Elbuken, Aykutlu Dana,