| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7146012 | Sensors and Actuators B: Chemical | 2015 | 7 Pages |
Abstract
Surface acoustic wave (SAW) sensors using Love wave were designed and fabricated with SiO2-coated piezoelectric LiNbO3 wafers for Influenza A viral antigen detection, in which the targeted analyte was selectively captured at the surface through the antigen and antibody interaction enabled with appropriate surface functionalization. It was found that triethoxysilylbutylaldehyde (ALTES) and triethoxysilylundecanal ethylene glycol acetal (ACTES) are effective chemical reagents for immobilizing Influenza A hemagglutinin (HA) antibodies on the SiO2/LiNbO3 SAW surface. The detection limit of Influenza A HA H1N1 antigen at an analyte concentration as low as 1 ng mLâ1 was demonstrated without any compensation design at room temperature with our obtained SAW sensors with the HA antibodies immobilized at ALTES-functionalized surface.
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Authors
Ying Jiang, Chin Yaw Tan, Sze Yu Tan, Miki Shi Fei Wong, Yi Fan Chen, Lei Zhang, Kui Yao, Samuel Ken En Gan, Chandra Verma, Yee-Joo Tan,