Ag nanoparticles and electrospun CeO2-Au composite nanofibers modified glassy carbon electrode for determination of levofloxacin

A simple and novel electrochemical sensor was developed to determine levofloxacin based on the Ag nanoparticles/electrospun CeO2-Au composite nanofibers modified glassy carbon electrode (AgNPs/CeO2-Au/GCE). The electrospun CeO2-Au composite nanofibers provided a stable matrix and a large surface area for the fabrication of the sensing interface while the Ag nanoparticles dramatically promoted the current of levofloxacin on the electrode. Scanning electron microscopy and electrochemical methods were used to characterize the AgNPs/CeO2-Au composite film. The oxidative peak current was linear with the levofloxacin concentration in the range of 0.03-10 μM. The detection limit was as low as 0.01 μM (S/N = 3), and the sensitivity could reach 1240 μA mM−1 cm−2. Furthermore, the proposed modified electrode also could be feasibly applied to the determination of levofloxacin in human urine and blood serum samples.