Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7149258 | Sensors and Actuators B: Chemical | 2013 | 7 Pages |
Abstract
A sensitive nanopore-based analytical method was developed for the detection of cyclohexyl methylphosphonic acid (CMPA) and pinacolyl methylphosphonate (PMPA), hydrolytes of nerve agents soman and cyclosarin, respectively. The method uses a multi-functionalized α-hemolysin protein ion channel as the sensing element, with a host molecule β-cyclodextrin lodged in the lumen of the channel as a molecular adapter. The capture and release of CMPA/PMPA by the β-cyclodextrin host caused current modulations in the nanopore. Since the event residence times and amplitudes were significantly different, CMPA and PMPA could conveniently be differentiated and simultaneously quantitated.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jyoti Gupta, Qitao Zhao, Guihua Wang, Xiaofeng Kang, Xiyun Guan,