Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7211474 | Beni-Suef University Journal of Basic and Applied Sciences | 2017 | 22 Pages |
Abstract
The one-pot three-component reaction for the synthesis of pyrido[2,3-d]pyrimidine derivatives has been reported via initial Knoevenagel, subsequent addition and final heterocyclization of substituted aromatic aldehydes, cyanoacetamide and 6-aminouracil in N,N-dimethylformamide (DMF) solvent using 4-dimethylaminopyridine (DMAP) as new organocatalyst under ultrasound irradiation. The results showed that a series of aromatic aldehydes were successfully used to prepare the targeted pyrido[2,3-d]pyrimidine derivatives with good to excellent yields (81-93%) and there is no major effect on the yield of product by electron donating/withdrawing substituents. Short reaction time, environment friendly procedure, excellent yields, inexpensive and readily available catalyst are the advantages of this procedure. All synthesized compounds were characterized by IR, 1HNMR, 13CNMR and mass spectral data.
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Authors
Ajmal R. Bhat, Gowhar A. Naikoo, Israr Ul Hassan, Rajendra S. Dongra, Tabassum Ara,