Article ID Journal Published Year Pages File Type
7222032 Nonlinear Analysis: Real World Applications 2018 16 Pages PDF
Abstract
We study a free boundary problem modeling solid tumor growth. The simplified model contains a parameter λ. Different from previous works on bifurcation analysis, a new ingredient of the present paper is that the influence of the extracellular matrix (ECM) and matrix degrading enzymes (MDE) interactions is included in the model. We first show that for each λ>0, there exists a unique radially symmetric stationary solution with radius r=RS. Then we prove that there exist a positive integer n∗ and a sequence of λn(n>n∗) for which branches of symmetry-breaking stationary solutions bifurcate from the radially symmetric one. In particular, we discover that these λn are larger than those λ˜n previously known when the effects of ECM and MDE are not considered in the model.
Related Topics
Physical Sciences and Engineering Engineering Engineering (General)
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