| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 724067 | IFAC Proceedings Volumes | 2007 | 6 Pages |
Abstract
Measurement of the key process variables is essential during biopharmaceutical production. These measurements are often not available online. This work combines frequent online measurements with infrequent offline measurements to estimate the specific growth rate, biomass, and the oxygen mass transfer coefficient during continuous and fed-batch cultivations of Bordetella pertussis online using an Extended Kalman filter, parameter adaptation, and learning.
Keywords
Related Topics
Physical Sciences and Engineering
Engineering
Computational Mechanics
Authors
Z.I.T.A. Soons, J. Shi, L.A. van der Pol, G. van Straten, A.J.B. van Boxtel,