Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
73325 | Microporous and Mesoporous Materials | 2013 | 7 Pages |
•Ferulic acid was intercalated in a zinc–aluminium layered double hydroxide.•The ferulic acid is controlled released from HDL under a biological media.•Released ferulic acid inhibits oxidation of human fibroblasts.•Oxidation of human fibroblasts is prevented for long time because of the controlled releasing.
Ferulic acid anions were intercalated in a Zn–Al layered double hydroxide. The materials generated by this process were characterised structurally and tested in two important applications: as in vitro drug delivery agents in a system that mimics biological conditions, for which a mathematical model describing the drug delivery profile was created, and as antioxidants for human fibroblasts.
Graphical abstractReleased ferulic acid from a hybrid layered double hydroxide reduces significantly the reactive oxygen species in human fibroblasts. Inhibition of oxidation occurs for periods as long as 24 h.Figure optionsDownload full-size imageDownload as PowerPoint slide