Chemical current conveyor (CCCII+): System design and verification for buffer index/capacity measurement

The pH and buffer index/capacity of a biomedical fluid, such as blood, provide useful clinical data for decisions on diagnosis and appropriate treatment. In this paper a novel system that has the capability of producing a useful miniaturised biosensor based, clinical instrument system providing simultaneous outputs of both pH and buffer index/capacity (β) is described. The system uses an ISFET as the primary sensing element and is based on the author's chemical current conveyor (CCCII+). A prototype has been constructed, and the results verify both the concept and viability of practical measuring system for pH and β.