A sensitive nitric oxide microsensor based on PBPB composite film-modified carbon fiber microelectrode

In this work, a sensitive electrochemical microsensor of nitric oxide (NO) was reported. The microsensor was constructed by coating PBPB composite on carbon fiber microelectrodes (CFME). The NO microsensor displayed excellent electrochemical activity toward the oxidation of NO and have the virtue of good stability, reproducibility and high sensitivity. Under optimal working conditions, the oxidation current of NO at this microsensor exhibited a good linear relationship with NO concentration in the range of 3.6 × 10−8 to 8.9 × 10−5 mol/L with a low detection limit of 3.6 × 10−9 mol/L (S/N = 3). The microsensor was successfully applied to the direct and real-time detection of NO release from biological samples, foreseeing the promising applications of this microsensor in fields like biology and medicine.