| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 74589 | Microporous and Mesoporous Materials | 2012 | 5 Pages |
A biocompatible nanovalve attached to the surface of MCM-41 mesoporous nanoparticles is designed to release encapsulated guest molecules controllably under pH activation. This nanovalve system is comprised of α-cyclodextrin (α-CD) rings that encircle p-anisidino linkers, and can be tuned to respond under specific pH conditions through chemical modification of the linkers. One of the distinctive features of this functional nanovalve system lies in its excellent bio-stability and durability in cell culture medium solution, the binding between the α-CD and p-anisidino groups was not interrupted or disintegrated by the proteins in the DMEM solution without adjusting the pH value. Luminescence spectroscopy demonstrates that the on-command pH-activated system displays very good bio-stability—no drug leakage at pH ∼7.4 and excellent drug release performance not only in H2O but also in cell culture medium at pH ∼5.5.
Graphical abstractA biocompatible pH-responsive drug delivery nanovalve system was designed, synthesized, and tested. The on-command pH-activated system displayed very good stability—no drug leakage at pH ∼7.4 and excellent drug release performance not only in H2O but also in cell culture medium at pH ∼5.5.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A biocompatible pH-responsive nanovalve was designed based on MCM-41 mesoporous nanoparticles. ► The nanoparticles possess uniform small size and good monodispersion. ► The on-command pH-activated system displays very good bio-stability. ► No drug leakage was observed in cell culture medium solution before the pH was tuned. ► The nanovalve system exhibits excellent drug release performance not only in H2O but also in cell culture medium at pH ∼5.5.
