Surface plasmon resonance investigation of two-dimensional organic–inorganic hybrid materials with mouse IgG

A novel two-dimensional organic–inorganic hybrid material containing mouse immunoglobulin G (layered carboxylpropylamidephenylsilica-mouse immunoglobulin G: CPAPhS-mouse IgG) was developed to enhance the sensitivity of the chip used for surface plasmon resonance (SPR). Mouse IgG was covalently attached to the layered CPAPhS using well-established active ester chemistry. CPAPhS-mouse IgG was facilely fabricated onto the Au surface to acquire a novel surface plasmon resonance (SPR) sensor chip, which exhibits higher sensitivity in the detection of the anti-mouse IgG. More interestingly, two different kinds of adsorption equilibrium were exhibited in the unique sensorgram of the anti-mouse IgG, likely due to the unique material structure of the sensor chip.