| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 750734 | Sensors and Actuators B: Chemical | 2015 | 6 Pages |
A fluorescent probe, 1-pyrenecarboxaldehyde, 2-phenylhydrazone (1), has been successfully developed for the detection of hypochlorite on the basis of a specific reaction with phenylhydrazone. The design strategy for the probe is based on the strong quenching effect of electron-donor phenylhydrazone on pyrene fluorescence via the photoinduced electron transfer process, and is accomplished through constructing the conjugated molecule by using a cleavable CN bond as a linker. This probe reacts selectively with hypochlorite over other ions and reactive oxygen species (ROS), accompanied by 42.6-fold fluorescence enhancement. Biological imaging studies using living cells (HeLa cells) to detect hypochlorite are successfully demonstrated.
Graphical abstractPyrene phenol–hydrazone is reported here as a novel “turn on” fluorescent probe for the highly selective and sensitive detection of hypochlorite in aqueous solution.Figure optionsDownload full-size imageDownload as PowerPoint slide
