| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 750851 | Sensors and Actuators B: Chemical | 2015 | 8 Pages |
•The oxidase like property of FAnPVnMo12−nO40 (FAPMoVn, n = 1, 2 and 3) was found.•It is found that FAPMoV3 exhibited higher activity than the other two species.•Investigated the morphologies during the storages and the immunoassay of tumor cells.•The morphologies could influence the assay result, and suggested to be used in flesh.
A series of inorganic-biomolecular hybrids FAnPMo12−nVnO40 (n = 1, 2, and 3, abbreviated as FAPMoVn, FA represents folic acid) had been synthesized through self-assembly of bioactive molecules folic acids and phosphovanadomolybdates. These folate-functionalized hybrids had been proved to possess unique oxidase-like activity in the oxidation of dyes, which can catalyze oxidation of the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) by air to form a blue color in aqueous solution. Among all hybrids, FAPMoV3 performed best. Based on their oxidase property, an approach instead of traditional horseradish peroxidase (HRP)-labeled assay for the visual detection of cancer tumors by FAPMoV3 had been built up. FAPMoV3 exhibited fast response and high efficiency in colorimetric immunoassay of cancer cells at a neutral pH condition.
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