Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7519033 | Journal of Clinical Epidemiology | 2018 | 12 Pages |
Abstract
More than 85% of the c-RCTs failed to demonstrate a beneficial effect on a predefined primary endpoint. All but one study were overly optimistic with regard to the expected treatment effect. This highlights the importance of weighing up the potential merit of new treatments and planning prospectively, when designing clinical studies in a general practice setting.
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Authors
Andrea Siebenhofer, Michael A. Paulitsch, Gudrun Pregartner, Andrea Berghold, Klaus Jeitler, Christiane Muth, Jennifer Engler,