| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7520396 | Journal of Clinical Epidemiology | 2016 | 9 Pages |
Abstract
We discuss the role of such investigations (in the style of Mendelian randomization), and what they add to our understanding of potential causal mechanisms. If the genetic variants are selected solely according to statistical criteria, and the biological roles of genetic variants are not investigated, this may be little more than what can be learned from a well-designed classical observational study.
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Authors
Stephen Burgess, Adam S. Butterworth, John R. Thompson,