Article ID Journal Published Year Pages File Type
7556531 Analytica Chimica Acta 2012 14 Pages PDF
Abstract
► A novel simplex method best suited to coarsely gridded data was developed. ► This is used for 'sweet spot' identification in two bioprocess development studies. ► The method returns comparable experimental costs to those from DoE methodologies. ► The method is a viable alternative for 'sweet spot' identification in scouting studies.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Analytical Chemistry
Preview
The hybrid experimental simplex algorithm - An alternative method for 'sweet spot' identification in early bioprocess development: Case studies in ion exchange chromatography
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