Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7560207 | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics | 2018 | 40 Pages |
Abstract
Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition that is often refractory to standard frontline antidepressant therapy. A promising new approach to PTSD therapy is administration of a single sub-anesthetic dose of (R,S)-ketamine (Ket). The treatment produces rapid and significant therapeutic response, which lasts for only 4-7â¯days. In one of our studies, the mean duration of response was increased to 33â¯days when Ket administration was combined with a mindfulness-based cognitive therapy, Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER). We now report the results from a 20-patient study, which examined the duration of sustained response with combined TIMBER-Ket therapy, TIMBER-K arm, relative to the response observed in a placebo-controlled arm, TIMBER-P. A significant difference in the duration of response was observed between TIMBER-K and TIMBER-P arms: 34.44â¯Â±â¯19.12â¯days and 16.50â¯Â±â¯11.39â¯days, respectively (pâ¯=â¯0.022). Previous studies identified a negative correlation between antidepressant response to Ket and basal plasma concentrations of d-serine (DSR). In this study, the basal DSR levels positively correlated with the pre-treatment severity of PTSD symptoms (Pearson's râ¯=â¯0.42, pâ¯=â¯0.07) and patients with basal DSR levelâ¯â¥â¯3.5â¯Î¼M displayed not only higher PTSD severity but also shorter duration of response. The data indicate that basal DSR levels may serve as a biomarker of the severity of PTSD symptoms and as a predictor of clinical response. This article is part of a Special Issue entitled: d-Amino acids: biology in the mirror, edited by Dr. Loredano Pollegioni, Dr. Jean-Pierre Mothet and Dr. Molla Gianluca.
Keywords
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Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Basant Pradhan, Ludmil Mitrev, Ruin Moaddell, Irving W. Wainer,