Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7586333 | Food Chemistry | 2018 | 36 Pages |
Abstract
Isoflavones have an affinity for estrogen receptors (ERs) including beneficial affinity for ERβ. Widely used soy is a source of poorly absorbed isoflavones glycosides. Red clover contains mostly easily absorbed free aglycones. Red clover sprouts were cultivated under different conditions (white light, UVA or UVB for 12 or 24â¯h a day at 18 or 25â¯Â°C) to maximise the content of isoflavones, especially of high affinity for ERβ. The affinity of isoflavones to ERs was evaluated by molecular modelling and isothermal titration calorimetry (ITC). The richest source of isoflavones, especially formononetin were sprouts cultivated for 10 days under continuous white light and at 25â¯Â°C (562â¯mg/100â¯g of fresh mass). Formononetin and the above sprouts has been shown to have a high affinity for ERβ. Red clover sprouts can be considered as a source of phytoestrogens with high biological activity and as a dietary supplement reducing menopausal symptoms.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Grażyna Budryn, Ilona GaÅÄ
zka-Czarnecka, Ewelina Brzozowska, Joanna Grzelczyk, RadosÅaw Mostowski, Dorota Å»yżelewicz, José P. Cerón-Carrasco, Horacio Pérez-Sánchez,