Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7632616 | Journal of Pharmaceutical and Biomedical Analysis | 2012 | 6 Pages |
Abstract
⺠This paper discusses a novel quantitative proton magnetic resonance method for capsular polysaccharide of X serogroup, a critical target for the next generation of meningococcal vaccines. ⺠The method has is linear, accurate, precise (under intermediate precision conditions) and rugged. ⺠The first total NMR assignment of the polysaccharide combining correlation experiments of 1H, 13C and 31P nuclei is reported. ⺠The quantitative NMR method and the NMR assignments discussed are valuable tools for further studies, especially in vaccine candidates.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Raine Garrido, Alain Puyada, AnaÃs Fernández, Majela González, Ubel RamÃrez, Felix Cardoso, Yury Valdés, Domingo González, Violeta Fernández, Vicente Vérez, Hermán Vélez,