Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
76697 | Microporous and Mesoporous Materials | 2008 | 8 Pages |
Carbamazepine is an antiepileptic drug characterized by poorly water solubility that affects negatively its bioavailability. Here we report on the ability of the mesoporous silicate MCM-41 to act as a vehicle able to improve the drug dissolution rate by preventing drug crystallization. Carbamazepine was adsorbed into nanopores of MCM-41 and the drug loaded MCM-41 was characterized by X-ray powder diffraction, N2 adsorption, FT-IR spectroscopy and thermogravimetric and differential scanning calorimetry analyses. Carbamazepine loading resulted 14% and the drug was not arranged in crystalline form. In vitro drug release results showed a remarkable increase of carbamazepine dissolution rate in all the different tested media. As this improvement is due both to the high specific surface area of loaded MCM-41 and to the lack of crystalline drug, storage stability studies at different environment conditions were conducted in order to investigate the ability of MCM-41 to prevent drug crystallization.