Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7677 | Biomaterials | 2011 | 10 Pages |
Abstract
Target ligand folic acid (FA) and cell-penetrating peptide octaarginine (R8) were coupled with the gene vectors (PEI600-CyD, PC) composed of β-cyclodextrin (β-CyD) and low-molecular-weight polyethylenimine (PEI, Mw 600) to form nanovectors for highly efficient gene delivery to tumor cells. The resultant ternary nanocomplexes of FA-PC/R8-PC/pDNA produced excellent gene transfaction abilities in the folate receptor (FR)-positive tumor cells in vitro and in vivo. The FR-mediated endocytosis and the R8-mediated transmembrane functionality together contributed to the high transfection levels. This study provides a promising means to produce gene nanovectors for in vivo applications.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Qi-Ying Jiang, Li-Hua Lai, Jie Shen, Qing-Qing Wang, Fu-Jian Xu, Gu-Ping Tang,