| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7753571 | Journal of Inorganic Biochemistry | 2018 | 31 Pages |
Abstract
Bacillus methanolicus CYP152K6 is a novel cytochrome P450 (P450 or CYP) peroxygenase family member. Its tetradecanoic acid-bound crystal structure reveals that the substrate binds through its carboxylate to a conserved arginine residue. Hydrogen peroxide displaces the distal water on the heme, forming a reactive iron-oxo species that catalyzes substrate oxidation.332
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hazel M. Girvan, Harshwardhan Poddar, Kirsty J. McLean, David R. Nelson, Katherine A. Hollywood, Colin W. Levy, David Leys, Andrew W. Munro,