Structural diversity in dinuclear copper(I) halide complexes of 2,4-dithiouracil: Synthesis, crystal structures, induction of DNA damage and oxidative stress mediated by ROS

Three dinuclear copper(I) halide complexes containing 2,4-dithiouracil and triphenylphosphine with different bridging motifs, namely doubly bridged [Cu2(μ-Cl)(μ-S,S-dtucH)(PPh3)4], single bridged [Cu2Br2(μ-S,S-dtucH2)(PPh3)4] and triply bridged [Cu2(μ-I)2(μ-S,S-dtucH2)(PPh3)2] were isolated and structurally characterized. The compounds were also screened for their ability to interact with CT-DNA in vitro and to produce reactive oxygen species (ROS).