| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7796887 | European Journal of Medicinal Chemistry | 2018 | 34 Pages |
Abstract
A series of C3-O-neoglycosides and C3-MeON-neoglycosides of digoxigenin were synthesized. The SAR analysis revealed that C3-O-neoglycosides of digoxigenin exhibited stronger cytotoxicity and induction of Nur77 expression of tumor cells than C3-MeON-neoglycosides. Among them, 3β-O-(β-l-fucopyranosyl)-digoxigenin (3i) showed the highest activity on induction of Nur77 expression and translocation from the nucleus to cytoplasm, leading to cancer cell apoptosis.251
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao-san Li, Yi-chang Ren, Yu-zhou Bao, Jie Liu, Xiao-kun Zhang, You-wei Zhang, Xue-Long Sun, Xin-sheng Yao, Jin-Shan Tang,