Synthesis, characterization, crystal structure and urease-inhibition activities of three 2-phenylthiazole derivatives

Three 2-phenylthiazole derivatives were synthesized were synthesized, characterized by FT-IR, 1H NMR and 13C NMR spectroscopy. Their crystal structures were also determined by single-crystal X-ray diffraction studies. A detailed analysis of the intermolecular contacts were performed based on the Hirshfeld surfaces, their 2D fingerprint plots. The urease-inhibition activities of the synthesized compounds were tested by phenol red method. Among the three compounds, the compound N-cyclohexyl-2-(4-methoxyphenyl)thiazole-4-carboxamide (5b) showed the best urease inhibitory activity with the IC50 of 1.82 μM. The compound could interact with the catalytic active site of urease.104