Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7806623 | Journal of Molecular Structure | 2018 | 11 Pages |
Abstract
Three 2-phenylthiazole derivatives were synthesized were synthesized, characterized by FT-IR, 1H NMR and 13C NMR spectroscopy. Their crystal structures were also determined by single-crystal X-ray diffraction studies. A detailed analysis of the intermolecular contacts were performed based on the Hirshfeld surfaces, their 2D fingerprint plots. The urease-inhibition activities of the synthesized compounds were tested by phenol red method. Among the three compounds, the compound N-cyclohexyl-2-(4-methoxyphenyl)thiazole-4-carboxamide (5b) showed the best urease inhibitory activity with the IC50 of 1.82â¯Î¼M. The compound could interact with the catalytic active site of urease.104
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Authors
Da-Hua Shi, Xiao-Dong Ma, Zong-Ming Tang, Tong Dong, Bao-Yun Xu, Yu-Wei Liu, Xiao-Kai Song, Wei-Wei Liu, Meng-Qiu Song,