Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7806927 | Journal of Molecular Structure | 2018 | 19 Pages |
Abstract
The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of biological properties to different derivatives. Thus, synthetic methods have been developed to obtain such molecules. Herein, we describe the heterocyclization process to obtain imidazolidine-2,4-diones (hydantoin compounds) from methylcyclobutyl ketones and cyclobutanones derived from (â)-(1S)-α-pinene and (â)-(1S)-verbenone through the Bucherer-Berg reaction. The methylcyclobutyl hydantoins and the spirohydantoin obtained were fully characterized, determining their absolute stereochemistry by nuclear magnetic resonance experiments and theoretical calculations.
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Authors
Juan Caturelli, M. Florencia Martini, Lucas Fabian, Graciela Y. Moltrasio, Albertina G. Moglioni,