2D correlation Raman spectroscopy of model micro- and nano-carbon layers in interactions with albumin, human and animal

To unravel the carbon layer-albumin interaction 2D correlation Raman microspectroscopy was applied, checking also the importance of its origin, animal or human. 2D correlation confirms that albumin adheres to the surface of both studied carbon layers. Additionally, it allowed to resolve additional valuable characteristic, which is not directly visible in the Raman spectra. For C (CVD) carbon layer a change in albumin conformation was observed, but for nano-MWCNTs layer interactions with particular amino acid side chains with the surface was seen. Differences between albumins can drive on the synthetic material-albumin interactions.