Synthesis and crystal structure of quinolinium salt: Assignment on nonsteroidal anti-inflammatory activity and DNA cleavage activity

To develop new anti-inflammatory and DNA cleavage agent with improved pharmaceutical profile, five quilinium salt based compounds have been synthesized and x-ray characterization of these quinolinium salts have been reported here. These quinolinium salts have potential to show the better anti-inflammatory activity as well as DNA cleavage activity. The anti-inflammatory activities of quinolinium salts 1-5 have been evaluated by complete Freund's adjuvant (CFA) induced rat paw edema method. The DNA cleavage activities of quinolinium salts 1-5 were analyzed by using plasmid pBR322. The crystal structure of quinolium salt 1, 2 and 3 have shown the intermolecular non-covalent interactions such as cation···π, π···π, CH···π, CH···X (X = I and Br) and CH⋯N interactions.