| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7807978 | Journal of Molecular Structure | 2018 | 5 Pages |
Abstract
Among others poly(ε-caprolactone) (PCL) is a biocompatible and biodegradable material with low cytotoxicity that is widely adopted as synthetic polymer in several applications. However, it is hydrophobic, which limits its use in tissue engineering. In order to improve its hydrophilicity and cellular compatibility, PCL surface was grafted with maltose through a two-step procedure in which controlled aminolysis of PCL ester bonds by hexanediamine was followed by reductive amination with the carbohydrate reducing end. The modified PCL surface was then characterized in detail by x-ray Photoelectron Spectroscopy (XPS) and Near Edge x-ray Absorption Fine Structure (NEXAFS) spectroscopies. In addition, the biocompatibility of the proposed biomaterial was investigated in preliminary biological assays.
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Authors
Valeria Secchi, Roberto Guizzardi, Laura Russo, Valentina Pastori, Marzia Lecchi, Stefano Franchi, Giovanna Iucci, Chiara Battocchio, Laura Cipolla,