Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7810781 | Journal of Molecular Structure | 2013 | 9 Pages |
Abstract
A convenient pathway for the synthesis of new of β-aryl-δ-iodo-γ-lactones is described. The synthetic route led to both cis and trans isomers which were separated by column chromatography or crystallization. The structures of synthesized compounds were confirmed by spectroscopic methods: IR, NMR and HR-MS. For lactones with naphthyl ring (6e and 7e) the crystal structures were also obtained. The lactones were screened for biological evaluation against cancer line HL-60 (human promyelocytic leukemia). The tests showed that the presence of substituent at the benzene ring does not significantly affect the antiproliferative activity of the compound.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alicja Wzorek, Barbara Gawdzik, Witold GÅadkowski, Mariusz Urbaniak, Anita BaraÅska, Maura MaliÅska, Krzysztof Woźniak, Katarzyna KempiÅska, Joanna Wietrzyk,