Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7810805 | Journal of Molecular Structure | 2013 | 7 Pages |
Abstract
The inclusion complex of coenzyme Q10 (CoQ10) by γ-cyclodextrin (γ-CD), CoQ10-CD complex, was recently developed. The addition of the CoQ10-CD complex recovered the growth of a fission yeast mutant strain, Îdps1, which otherwise cannot grow well due to the lack of coenzyme Q producing ability. However, the oxygen consumption rate of this strain was not restored by the addition of the CoQ10-CD complex. The addition of two other anti-oxidative reagents, glutathione and ascorbic acid, also recovered the growth of the Îdps1 strain as well. These results indicated that the recovery of the growth of Îdps1 was brought about by the anti-oxidative property of CoQ10. The intensity of Raman spectra of Îdps1 at 1602 cmâ1, which is prominently observed for the wild type of the fission yeast, was compared between before and after addition of the CoQ10-CD complex. The signal was very weakly observed for Îdps1 and did not increase in intensity by the addition of the CoQ10-CD complex. These results suggested the recovery of the growth of Îdps1 was brought about not by the restoration of respiration function of Îdps1 but by the anti-oxidative property of CoQ10 to result in the decrease in the oxidative stress.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tatsuro Nishida, Tomohiro Kaino, Ryo Ikarashi, Daisuke Nakata, Keiji Terao, Masahiro Ando, Hiro-o Hamaguchi, Makoto Kawamukai, Tatsuyuki Yamamoto,